Cause of Protein Deficiency-Related Joint Pain

Cause of Protein Deficiency-Related Joint Pain

Vitamin Deficiency

What are the benefits of riboflavin?

Riboflavin (vitamin B2) is a water-soluble and heat-stable vitamin that boosts energy and acts as an antioxidant for cellular protection. From StatPearls, a publication of NCBI Bookshelf (Jul 18, 2022), riboflavin is used by the body to metabolize fats, proteins and carbohydrates into glucose for energy. In addition, adequate riboflavin intake helps to maintain healthy red blood cells.

Can vitamin D deficiency cause joint pain?

Low levels of vitamin D can lead to increased joint and muscle pain, according to research from Medical News Today in 2018. Vitamin D deficiency can negatively affect both physical and mental wellbeing, and medical professionals should be aware of this when diagnosing potential causes of joint pain.

How can scurvy be prevented?

Scurvy is a clinical syndrome caused by vitamin C deficiency, first reported in 1550 BC. Mentioned in NCBI Bookshelf, it can be prevented with a diet that includes vitamin C-rich foods. Symptoms include bruising, bleeding gums, fatigue, and joint pain.

Nutrient Deficiency

Can a balanced diet help avoid protein deficiency?

It is virtually impossible to design a calorie-sufficient diet which is lacking in protein and any of the amino acids, according to a study published in 2018 by the National Institutes of Health. Protein deficiency is an extremely rare nutrient deficiency and can be easily avoided with a balanced diet.

Can vitamin D deficiency affect physical and mental functions?

Low levels of vitamin D can increase joint and muscle pain, according to several studies, though the research to date is inconclusive. A study released in 2018 by the University of Tehran suggests that a vitamin D deficiency can affect physical and mental functions. Research published in 2017 found that people with osteoarthritis had significantly lower levels of vitamin D than those without the condition.

Can protein deficiency cause pain?

Chronic protein deficiency can cause muscle and joint pain, according to research from Brown University. Protein is essential for the formation and repair of muscle tissue, as well as providing a protective layer around joints to prevent wear and tear. Other signs of protein deficiency include fatigue, weakened immune system, low blood pressure, and slow healing of wounds.

Low Protein Intake

Can a lack of protein cause health issues?

Not getting enough protein can lead to swelling, fatigue, and other health issues. From WebMD, one of the most common signs of protein deficiency is swelling, especially in the abdomen, legs, feet, and hands. Research has shown that a lack of protein can also lead to fatigue and impair the body's ability to recover from illness or injury.

Can a vegan diet help with fibromyalgia-related joint pain?

A vegan diet may be beneficial for alleviating joint pain associated with fibromyalgia, as suggested by a study published in the Scandinavian Journal of Rheumatology. As vegan diets exclude foods which are high in protein, this implies that a low protein intake may be beneficial for reducing joint pain. Research conducted by the University of North Carolina School of Medicine has found that increased protein intake may be linked to increased joint pain.

Can protein deficiency cause hunger and fatigue?

People with protein deficiency experience a range of symptoms, such as hunger, fatigue, difficulty concentrating and hair loss. According to SELF, low protein intake can lead to decreased levels of the hormone ghrelin, which is responsible for hunger, and increased levels of hormones that make you feel full. Studies have shown that adequate protein intake is essential for healthy muscle growth and maintenance.


What is malabsorption?

Malabsorption is a disorder which affects the ability to absorb nutrients from food, leading to indigestion and malnutrition. From Cleveland Clinic, it is an umbrella term for a wide range of disorders, and is caused by a three-part process of digestion. Malabsorption can be treated with dietary modifications or medications.

Malabsorption is a condition characterized by impaired nutrient absorption or digestion in the gastrointestinal tract, leading to poor nutrient absorption. Attributed to StatPearls (NCBI Bookshelf, 2022), it can result in deficiencies in fats, carbohydrates, proteins, vitamins, minerals, and trace elements. To prevent further health complications, proper diagnosis and treatment of malabsorption are important.

Malabsorption can cause nutrient deficiencies resulting in weight loss, difficulty maintaining weight, and stopped menstruation in women. Sourced from Merck Manuals, malabsorption can cause deficiencies of all nutrients or selective deficiencies of proteins, fats, sugars, vitamins, or minerals. The symptoms vary depending on the specific deficiencies.

Inflammatory Response

What are the five signs of inflammation?

Inflammation is a part of the body's natural defense mechanism against infectious or non-infectious etiologies, and is characterized by five fundamental signs. According to StatPearls (NCBI, 2022), these signs include redness, heat, swelling, pain, and loss of function. Inflammation helps to fight off infection by activating the immune system.

What are the symptoms of joint inflammation?

Joint inflammation is caused by an injury or illness, and can cause difficulty in moving the affected joint, swelling, pain, and aching. According to Medical News Today, symptoms of joint inflammation include difficulty moving the affected joint or joints, swelling or bulging in the joint, pain or aching in the joint, and pain around the joint. Treatment typically involves rest, physical therapy, medications and lifestyle changes.

Can CitVim trigger an autoimmune response in people with rheumatoid arthritis?

Rheumatoid arthritis is an inflammatory disease of the synovium, which is linked to a protein called citrullinated vimentin (CitVim). A study from the National Institutes of Health (NIH) in 2020 found that CitVim can trigger an autoantibody response in some people with rheumatoid arthritis. This autoantibody response is believed to be related to the development and progression of the disease.

Low Immunity

Can eating protein help treat hypoproteinemia?

Hypoproteinemia is a condition in which a person has very low protein levels in the blood, causing symptoms such as fatigue and weakness. According to Medical News Today, consuming enough protein can help treat this condition. Other treatments may be necessary depending on the cause of the hypoproteinemia.

What protein has been linked to the development of rheumatoid arthritis?

A recent study from the National Institutes of Health (NIH) has identified a protein implicated in the development of rheumatoid arthritis, a painful and debilitating inflammatory disease. This finding could lead to improved treatments and therapies for those suffering from this condition. The research indicates that the protein, called TGF-?RII, is a key factor in the onset of rheumatoid arthritis and could be used to develop drugs that target this protein in order to reduce inflammation and reduce joint damage. Understanding TGF-?RII may provide insight into the development of other autoimmune diseases.

What are the signs and symptoms of primary immunodeficiency?

Primary immunodeficiency is a disorder that can cause frequent and recurrent infections, inflammation and infection of internal organs, blood disorders, and digestive problems. From Mayo Clinic, signs and symptoms of primary immunodeficiency include pneumonia, bronchitis, sinus infections, ear infections, meningitis and skin infections, along with low platelet count or anemia, cramping, loss of appetite, nausea and diarrhea. Treatment for primary immunodeficiency typically involves medications and lifestyle changes.

Hormone Imbalance

What are the symptoms of hormonal imbalance?

Hormonal imbalance can cause a variety of symptoms, such as weight gain, fat accumulation between the shoulders, and sudden mood changes. According to Healthline, common hormonal conditions affecting people of all genders may be the cause. Hormones play an important role in regulating metabolism and appetite, which can contribute to weight gain or difficulty losing weight.

What can be done to manage hypoproteinemia?

Hypoproteinemia is a condition characterized by low levels of protein in the blood, which can lead to fatigue, weakness, and increased susceptibility to infection. Sourced from Medical News Today, the condition can be effectively managed through dietary changes and supplementation. Regular checkups with a healthcare professional are recommended to monitor protein levels.

Can progesterone deficiency cause joint and muscle pain?

Progesterone deficiency is a significant cause of joint and muscle pain, particularly among women. This is because progesterone is a hormone that the body naturally produces. Attributed to an article on, joint pain can be caused by a lack of progesterone in the body, as it helps to protect joints and muscles. Progesterone also has anti-inflammatory properties which can reduce joint discomfort.

Oxidative Stress

How can lifestyle habits affect oxidative stress in the body?

Oxidative stress is associated with a range of chronic diseases, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer, as it leads to structural defects at a mitochondrial DNA level and functional alteration of enzymes and cellular structures. An info from a study conducted by Frontiers in Physiology in 2020, lifestyle habits can increase or decrease the levels of oxidative stress in the body. Antioxidants are important factors in managing oxidative stress levels and preventing diseases associated with it.

Can targeting interleukin-6 reduce rheumatoid arthritis symptoms?

A protein known as interleukin-6 (IL-6) has been implicated as a major contributor to rheumatoid arthritis, according to a study conducted by the National Institutes of Health in 2020. This finding suggests that targeting IL-6 may be an effective way to reduce inflammation and symptoms associated with the disease. Studies have found that IL-6 increases the production of pro-inflammatory molecules in the body, which could explain the connection between it and rheumatoid arthritis.

What is oxidative stress?

Oxidative stress is a state of imbalance between the body's free radicals and antioxidants, caused by an uneven number of electrons in oxygen-containing molecules. According to Healthline, oxidative stress can lead to a wide range of diseases and health conditions. Research suggests that oxidative stress may contribute to the development and progression of certain chronic conditions, such as Alzheimer's disease, diabetes, and cancer.

Genetic Predisposition

What diseases are related to collagens?

Collagens are related to many diseases, including osteogenesis imperfecta, chondrodysplasias, Ehlers-Danlos syndrome, Alport syndrome, Bethlem myopathy, epidermolysis bullosa, Knobloch syndrome, osteoporosis, arterial aneurysms, osteoarthrosis, and intervertebral disc disease, according to a study published by the National Center for Biotechnology Information in 2001. These diseases can have a range of symptoms and effects on the body.

What is osteoarthritis?

Osteoarthritis is a degenerative joint condition that develops over many years, causing pain, swelling, and deformity of the affected joint. Via Cleveland Clinic, inflammation and injury to the joint can cause bony changes, deterioration of tendons and ligaments, and cartilage breakdown. These changes can lead to difficulty in performing daily activities.

What is genetic predisposition?

Genetic predisposition is an increased likelihood of developing a certain disease based on one’s genetic makeup, as identified through family history and/or genetic alterations. As indicated by Verywell Health, this can contribute to the risk of developing the disease, but it does not guarantee that the disease will occur. Environmental factors can also influence the development of the disease.


How does dehydration affect joint pain?

Dehydration has a direct effect on joint pain, as it acts as a lubricant for joints and is estimated to make up 70-80% of joint cartilage. Via Orthopedic Associates, synovial fluid between joints gives them a cushioning effect and helps with mobility, and dehydration has been found to reduce the amount of lubrication available. It is important to stay hydrated in order to maintain healthy joint movement.

What causes dehydration?

Dehydration is caused by a loss of fluids and electrolytes due to diarrhea, vomiting, fever, or other factors, according to Mayo Clinic in 2021. In severe cases of acute diarrhea, a tremendous amount of water and electrolytes can be lost in a short period of time. Additional losses of fluids and minerals occur due to vomiting. It is important to drink plenty of fluids to help prevent dehydration.

What is Kwashiorkor?

Kwashiorkor is a severe form of protein malnutrition, affecting primarily infants and children up to the age of five. According to the NCBI Bookshelf, it is characterized by bilateral extremity swelling and is seen more commonly around the time of weaning. Kwashiorkor has been found to be associated with multiple medical complications.


  • Nih : Riboflavin Deficiency, StatPearls, - NCBI Bookshelf.
  • Nih : [Protein deficiency, a rare nutrient deficiency, ] - PubMed.
  • Webmd : Protein Deficiency, 7 Signs, You, Enough Protein, WebMD.
  • Clevelandclinic : Malabsorption, Syndrome, Symptoms, Causes, Treatment, - Cleveland Clinic.
  • Nih : Acute Inflammatory Response, StatPearls, NCBI.
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